The SynGen program for organic synthesis design

SynGen is a unique program for automatic organic synthesis generation. It focusses on the generation of the shortest, most economic synthetic routes for a given target organic compound, and is thus a useful tool for synthesis planning. It is based on Professor James B. Hendrickson's studies on efficiency in synthesis design and on the generalization of organic functionality and reactions.

• SynGen generates only the shortest and most efficient syntheses.
• SynGen generates the syntheses without user intervention, freeing it from user bias and allowing it to explore all possibilities.
• All the generated syntheses have commercially-available starting materials.

The MacOS version of SynGen is 1.2. We may port the program to Microsoft Windows and Linux/Unix, should there be sufficient funding.

Sample output

• Results summary: lysergic acid
• Sample routes:
  • Lysergic acid
    • route A106
    • route E48
    • route G3
    • route G6
    • route G9
  • Vetivone
    • route H16

System requirements

• Macintosh: PowerPC processor, MacOS 8.5 or later, 4-16 Mb RAM, 5 Mb disk space.
• Microsoft Windows: Not yet available.
• Linux/Unix: Not yet available.

Take a quick tour of the SynGen program.

Download the SynGen program.

Last updated on 21 May 2001.

Please send your comments to jbh@jbh.chem.brandeis.edu